Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel

Abstract

Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study we demonstrate a biomaterial with antimicrobial properties through incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.