Association of G22A variant of Adenosine Deaminase gene (ADA) with coronary-in-stent restenosis in coronary artery patients receiving drug-eluting stent: Short Communication

Abstract

The main problem with using stents in the treatment of coronary artery atherosclerotic stenosis in percutaneous coronary intervention (PCI) is In-stent restenosis (ISR). In this study, we investigated the possible role of the G22A variant of the Adenosine Deaminase gene (ADA) in the development of ISR. In this study, 91 patients who underwent PCI were divided into two groups: the case with ISR (n=40) and control without ISR after 6 months from stenting (n=51). The case and control groups were matched in terms of age and sex matching. The genotypes of the G22A variant in the samples were examined by the molecular method of PCR-RFLP and electrophoresis and the results were statistically analyzed by using t-test. The results of this study show that the frequency of allele A of variant G22A in (+ ISR) group is higher than (- ISR). However, there is no significant relationship between the distribution of allele and genotype frequency of this variant with the incidence of ISR (p>0.05).