Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases.

K. Usadel, J. Teuber, R. Paschke, M. Junker, U. Schwedes
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引用次数: 6

Abstract

After transplantation of human tissue to nu/nu mice the human lymphocytes disappear. In this context, interestingly, the DR-expression is not detectable anymore after transplantation of the tissues from patients with autoimmune thyrotoxicosis and cancer. Neopterin release was only demonstrable when T-lymphocytes from patients with autoimmune thyrotoxicosis or PHA-stimulated lymphocytes were added, independently of the presence of DR-expression in the used culture tissues. These results seem to exclude a functional role of DR-expression as a trigger mechanism of autoimmunity. It is supposed that DR-priming on epithelial cells is mediated by kinine production of activated T-lymphocytes or macrophages.
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人体内分泌组织移植到裸鼠:一种适合研究自身免疫性甲状腺疾病病理机制的体内模型
人组织移植到nu/nu小鼠体内后,人淋巴细胞消失。在这种情况下,有趣的是,在自身免疫性甲状腺毒症和癌症患者的组织移植后,dr -表达不再被检测到。只有当加入自身免疫性甲状腺毒症患者的t淋巴细胞或pha刺激淋巴细胞时,新蝶呤才能释放,而与使用的培养组织中dr表达的存在无关。这些结果似乎排除了dr -表达作为自身免疫触发机制的功能作用。据推测,上皮细胞上的dr启动是由活化的t淋巴细胞或巨噬细胞产生的激氨酸介导的。
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