Y. Ozeki, T. Mizuguchi, N. Hirabayashi, M. Ogawa, N. Ohmura, Miyuki Moriuchi, N. Harada, N. Matsumoto, H. Kunugi
{"title":"A Case of Schizophrenia with Chromosomal Microdeletion of 17p11.2 Containing a Myelin-Related Gene PMP22","authors":"Y. Ozeki, T. Mizuguchi, N. Hirabayashi, M. Ogawa, N. Ohmura, Miyuki Moriuchi, N. Harada, N. Matsumoto, H. Kunugi","doi":"10.2174/1874354400802010001","DOIUrl":null,"url":null,"abstract":"We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelin- related gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic link- age to 17p11, reduced expression of PMP22, and alterations in myelination have previously been reported, this report fur- ther suggests an etiological role of PMP22 in schizophrenia.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"68 4","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2008-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open psychiatry journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874354400802010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelin- related gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic link- age to 17p11, reduced expression of PMP22, and alterations in myelination have previously been reported, this report fur- ther suggests an etiological role of PMP22 in schizophrenia.