A Case of Schizophrenia with Chromosomal Microdeletion of 17p11.2 Containing a Myelin-Related Gene PMP22

Y. Ozeki, T. Mizuguchi, N. Hirabayashi, M. Ogawa, N. Ohmura, Miyuki Moriuchi, N. Harada, N. Matsumoto, H. Kunugi
{"title":"A Case of Schizophrenia with Chromosomal Microdeletion of 17p11.2 Containing a Myelin-Related Gene PMP22","authors":"Y. Ozeki, T. Mizuguchi, N. Hirabayashi, M. Ogawa, N. Ohmura, Miyuki Moriuchi, N. Harada, N. Matsumoto, H. Kunugi","doi":"10.2174/1874354400802010001","DOIUrl":null,"url":null,"abstract":"We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelin- related gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic link- age to 17p11, reduced expression of PMP22, and alterations in myelination have previously been reported, this report fur- ther suggests an etiological role of PMP22 in schizophrenia.","PeriodicalId":88755,"journal":{"name":"The open psychiatry journal","volume":"68 4","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2008-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open psychiatry journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874354400802010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

Abstract

We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelin- related gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic link- age to 17p11, reduced expression of PMP22, and alterations in myelination have previously been reported, this report fur- ther suggests an etiological role of PMP22 in schizophrenia.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
含有髓磷脂相关基因PMP22的17p11.2染色体微缺失一例精神分裂症
我们用比较基因组杂交(CGH)阵列和定量PCR方法报道了一例含有髓磷脂相关基因PMP22的17p11.2染色体缺失的精神分裂症患者。由于遗传联系-年龄与17p11, PMP22的表达减少,以及髓鞘形成的改变之前已经报道过,因此该报告提示PMP22在精神分裂症中的病因学作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Structural and Functional Neuroimaging Findings in Delusional Disorder: Diagnostic and Therapeutic Implications Association Between Anxiety Level of Child with Parental and PatientFactors During Preoperative Anesthesia Visit Patterns of Psychiatric Morbidity Before and After a War in Lebanon at Twelve Months Following Cessation of Hostilities Medical Professionalism in the U.S.: Under Vigorous Challenge by International medical graduate committee of gap Mind-Body Parallelism Revisited
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1