Female house mice develop a unique ovarian lesion in colonies that are at maximum population density.

J. C. Chapman, J. J. Christian, M. Pawlikowski, N. Yasukawa, S. D. Michael
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引用次数: 9

Abstract

Colonies of house mice reach maximum population density in 120-180 days, irrespective of cage size and initial number of colonizing animals. Reproduction ceases because the females become aggressive and unreceptive to mating. The aggressive behavior is correlated with elevated levels of testosterone (T) and corticosterone (B) (Chapman et al., Phys Behav 64:529-533, 1998). In two of seven strains of mice, females developed ovarian lesions. The occurrence of the lesion in one strain was correlated with the age of the animal and duration of the study. In the second strain, cage size was the determining factor. Lesioned ovaries weighed significantly more than nonlesioned ovaries. The lesion consisted of accumulations of luteal membrane and organelle fragments, and other cellular debris, suggestive of incomplete and prolonged luteolysis. Electron microscopic (EM) analyses revealed the presence of deposits of permanganate-resistant congophilic amyloid fibrils in the intima and smooth muscle cells of luteal thecal arteries. Population females had thymus glands and uteri that weighed significantly less than the same organs from females housed in the breeding colony, whereas the adrenal glands from the population females weighed significantly more. It is proposed that the female aggression is due to high levels of T. It is also proposed that the high levels of B suppress the immune cells involved in normal luteolysis and contribute to the incomplete and prolonged luteolysis.
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雌性家鼠在种群密度最大的群体中发展出一种独特的卵巢病变。
无论笼子大小和初始定殖鼠数如何,家鼠的种群密度在120-180天内达到最大。繁殖停止,因为雌性变得好斗,不愿交配。攻击性行为与睾酮(T)和皮质酮(B)水平升高相关(Chapman et al., Phys Behav 64:529-533, 1998)。在7个品系中的两个品系中,雌性小鼠出现卵巢病变。在一个菌株中病变的发生与动物的年龄和研究的持续时间相关。在第二菌株中,笼型大小是决定因素。受损卵巢的重量明显大于未受损卵巢。病变包括黄体膜和细胞器碎片的积累,以及其他细胞碎片,提示不完全和长期的黄体溶解。电镜(EM)分析显示,在黄体鞘动脉内膜和平滑肌细胞中存在抗高锰酸盐的嗜嗜性淀粉样蛋白原纤维沉积。雌性种群的胸腺和子宫的重量明显低于繁殖群体中雌性种群的相同器官,而雌性种群的肾上腺的重量明显大于雌性种群。认为雌性的攻击行为可能是由于高水平的t所致。同时,高水平的B抑制了参与正常黄体溶解的免疫细胞,导致黄体溶解不完全和延长。
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