Editorial for Nigerian Journal of Health Sciences: January–June 2017 issue

Abstract

Hydrocephalus occurs with excessive production and/or impaired drainage of cerebrospinal fluid, ultimately resulting in ventriculomegaly and other protean clinical manifestations. Ayannuga OA studied the histomorphometry of the lateral ventricle (LV) and cerebral cortex of Wistar rats following kaolin-induced hydrocephalus as well as the associated clinical manifestations. He found that clinical symptoms predated the morphological changes observed in the LV and cerebral cortex and concluded that cortical changes and ventriculomegaly were acute-phase features, while the detachment of the choroid plexus and reversal of cortical manifestations were features of chronicity.