Insulin-like growth factor binding protein 2 in bipolar disorder: An expression study in peripheral tissues

E. Milanesi, R. Zanardini, G. Rosso, G. Maina, A. Barbon, C. Mora, A. Minelli, M. Gennarelli, L. Bocchio-Chiavetto
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引用次数: 16

Abstract

Abstract Objectives: Insulin-like growth factor binding protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1–6) and appears to play a governing role in insulin-like growth factor (IGF) regulation in the central nervous system. This study aimed to investigate the putative involvement of IGFBP2 in mood disorder pathogenesis by measuring its expression levels in patient peripheral tissues. Methods: IGFBP2 protein and mRNA levels were measured in the serum of 93 controls, 41 bipolar disorder (BD) and 43 major depressive disorder (MDD) patients and in the skin fibroblasts from 15 controls, 12 BD and 23 MDD patients. Results: The results indicated reduced expression of IGFBP2 in both tissues of BD patients, whereas no difference was found in MDD patients compared with controls. Conclusions: Our findings in peripheral tissues are consistent with previous results in the brain and support a downregulation of IGFBP2 expression that is specific for BD, suggesting a role for this protein in the alterations in neurodevelopment and neuroprotection observed in the disorder. Further studies in independent and larger cohorts are warranted to confirm the involvement of IGFBP2 in BD.
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胰岛素样生长因子结合蛋白2在双相情感障碍中的外周组织表达研究
目的:胰岛素样生长因子结合蛋白2 (IGFBP2)是高亲和结合蛋白家族(IGFBP1-6)中的一员,在中枢神经系统的胰岛素样生长因子(IGF)调节中发挥调控作用。本研究旨在通过测量IGFBP2在患者外周组织中的表达水平,探讨IGFBP2在情绪障碍发病机制中的可能参与。方法:测定93例对照组、41例双相情感障碍(BD)和43例重度抑郁症(MDD)患者血清中IGFBP2蛋白和mRNA水平,以及15例对照组、12例双相情感障碍(BD)和23例重度抑郁症患者皮肤成纤维细胞中IGFBP2蛋白和mRNA水平。结果:结果显示IGFBP2在BD患者的两个组织中表达降低,而MDD患者与对照组相比无差异。结论:我们在外周组织中的发现与之前在大脑中的结果一致,并支持IGFBP2表达下调,这是BD特异性的,表明该蛋白在该疾病中观察到的神经发育和神经保护的改变中起作用。需要在独立和更大的队列中进行进一步的研究来证实IGFBP2在BD中的作用。
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