Cytokine Storm in COVID 19 Culminating in Candida Endocarditis

M. Kaneria, Abhijeet Budhe, Prasenjit Lade, Tejas Poyekar
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Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had made its demonic debut on the world stage in December 2019 and has been sweeping across the globe since then. 1 This new kid on the block soon also joined the cluster of risk factors, leading to fungal infections. Cases of mucormycosis, colloquially called “black fungus,” (COVID-19 associated mucormycosis [CAM]), had escalated in India, and the focus then shifted to Candida, the so-called “white fungus.” The dysregulated immune system in COVID-19, along with the immunosuppressants used to treat it, may give rise to fatal secondary infections. We present a patient who had a stormy, prolonged course following COVID-19, with multiple bacterial and viral infections, subsequently culminating in fungal endocarditis with Candida tropicalis.
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COVID - 19细胞因子风暴最终导致假丝酵母心内膜炎
由严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2)引起的冠状病毒病2019 (COVID-19)于2019年12月在世界舞台上恶魔般地首次亮相,此后席卷全球。这个新来的孩子很快也加入了导致真菌感染的危险因素。在印度,俗称“黑菌”的毛霉菌病(与COVID-19相关的毛霉菌病[CAM])病例已经升级,然后焦点转移到念珠菌,即所谓的“白色真菌”。COVID-19中失调的免疫系统,以及用于治疗它的免疫抑制剂,可能导致致命的继发感染。我们报告了一位患者,他在COVID-19后经历了暴风雨,延长了病程,伴有多种细菌和病毒感染,随后最终导致真菌性心内膜炎伴热带念珠菌。
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期刊介绍: Indian Association of Clinical Medicine is an academic body constituted in the year 1992 by a group of clinicians with the main aim of reaffirming the importance of clinical medicine in this era of high-tech diagnostic modalities. There is no doubt that modern investigational methods have contributed a lot to the present day medical practice but that does not render clinical acumen and examination less important. The art and science of clinical medicine helps up to make proper and judicious use of investigations and not these be the sole basis of our practice. That is the basic idea behind this ''Association''. We presently have members and fellows of the association from all over the country. In August, 2002 the body was registered as "Indian Association of Clinical Medicine" by the Registrar of Societies, Delhi.
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