Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Frontiers in Neuroendocrinology Pub Date : 2022-07-01 DOI:10.1016/j.yfrne.2022.100993

Wouter A.J. Vints , Oron Levin , Hakuei Fujiyama , Jeanine Verbunt , Nerijus Masiulis

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引用次数: 16

Abstract

Physical exercise may improve cognitive function by modulating molecular and cellular mechanisms within the brain. We propose that the facilitation of long-term synaptic potentiation (LTP)-related pathways, by products induced by physical exercise (i.e., exerkines), is a crucial aspect of the exercise-effect on the brain. This review summarizes synaptic pathways that are activated by exerkines and may potentiate LTP. For a total of 16 exerkines, we indicated how blood and brain exerkine levels are altered depending on the type of physical exercise (i.e., cardiovascular or resistance exercise) and how they respond to a single bout (i.e., acute exercise) or multiple bouts of physical exercise (i.e., chronic exercise). This information may be used for designing individualized physical exercise programs. Finally, this review may serve to direct future research towards fundamental gaps in our current knowledge regarding the biophysical interactions between muscle activity and the brain at both cellular and system levels.

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运动和长期突触增强:运动诱导的神经可塑性机制

体育锻炼可以通过调节大脑内的分子和细胞机制来改善认知功能。我们提出，体育锻炼(即运动因子)诱导的产物对长期突触增强(LTP)相关通路的促进是运动对大脑影响的一个关键方面。本文综述了由运动因子激活并可能增强LTP的突触通路。对于总共16种运动，我们指出了血液和大脑运动素水平是如何根据体育锻炼的类型(即心血管或阻力运动)以及它们对单次(即急性运动)或多次体育锻炼(即慢性运动)的反应而改变的。这些信息可用于设计个性化的体育锻炼计划。最后，这篇综述可能有助于指导未来的研究，以解决我们目前在细胞和系统水平上关于肌肉活动与大脑之间生物物理相互作用的知识的基本空白。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.