Modeling regulatory pathways with the use of the TRANSFAC system

Abstract

The TRANSFAC system of databases provides information about the molecular mechanisms of transcriptional regulation and pathological dysregulation, certain aspects of chromatin structure, and signal transduction. Integrating this information into a comprehensive system allows to model complex regulatory networks of experimentally known as well as hypothetical components, the latter ones being predicted by the application of state-of-the-art bioinformatics tools. Altogether, it will provide core information with which it ill be possible to tackle most of the problems in the field of “functional genomics”.