Glutathione S-transferase Isoenzymes in Lung Carcinoma Patients receiving Platinum-based Chemotherapy and Effects of Ethyl Alcohol and Smoking on Treatment Response

Abstract

Mostly observed in men, lung carcinoma, mostly observed in men, is one of the most frequent cancer types in Turkey and in the world. About two thirds of the lung carcinoma patients have inoperable lesions. 113 primary lung cancer patients who were receiving platinum based treatment at Chest Diseases and Chest Surgery Center of Ankara Atatürk Hospital were enrolled for the study. It was identified that 49 (43%) patients had GSTM1 gene deletion out of a group of 113. It was identified that 42 (%), 34 (39%) and 10 (12%) patients had 105 (wild type) genotype, İ le 105 /Val 105 (heterozygote) genotype and Val 105 /Val 105 (homozygote mutant) genotype, respectively out of a group of 113. GSTP1 is the most strongly expressed isoenzyme in the human lung. In this study, the responses to cisplatine based chemotherapy of homozygous and heterozygous patients with GSTP1 exon5 variant allele were observed to be similar to the responses of the patients carrying wild type genotype. it is displayed that wild type genes have positive effect on the response to treatment. This result yields that it is important to evaluate the effect of combination of GST genotype, alcohol ingestion amount, smoking frequency on the response to treatment