P. Meffert, J. Kühn, Baumeister Se, M. Lerch, J. Mayerle, H. Völzke
{"title":"Effects of the PNPLA3–SNP rs738409 on Serum Transaminase levels are modified by body mass index and alcohol consumption","authors":"P. Meffert, J. Kühn, Baumeister Se, M. Lerch, J. Mayerle, H. Völzke","doi":"10.15406/bbij.2018.07.00227","DOIUrl":null,"url":null,"abstract":"For the common rs738409 C>G SNP, which is located in the patatin-like phospholipase domain-containing protein 3 (PNPLA3), a strong association between non-alcoholic fatty liver disease (NAFLD) has been detected [1], approved [2-8] and expanded to an association with liver-fat content in general [8-13] and serum transaminase levels [14]. Also an association to a higher risk of progression to cirrhosis in NAFLD patients has been shown [15]. Transaminase levels, particularly of alanine transaminase (ALT) and aspartate transaminase (AST), are strong indicators of hepatic steatosis [16] as well as of cardio-metabolic risks [17] and are associated with mortality even within their reference ranges [18]. Yet, a small number of studies reported gene-environment interactions for rs738409. Recently it has been shown that the G allele of rs738409 is associated with lower serum triglyceride and cholesterol levels and higher ALT levels in overweight individuals only [19]. Children with the minor G allele had more liver fat per unit omega-fat intake than major homozygous children [20]. In another study, sugar and carbohydrate intake in Hispanic children was positively related to hepatic fat fraction in GG carriers but not in CG and CC carriers [21].","PeriodicalId":90455,"journal":{"name":"Biometrics & biostatistics international journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometrics & biostatistics international journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/bbij.2018.07.00227","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
For the common rs738409 C>G SNP, which is located in the patatin-like phospholipase domain-containing protein 3 (PNPLA3), a strong association between non-alcoholic fatty liver disease (NAFLD) has been detected [1], approved [2-8] and expanded to an association with liver-fat content in general [8-13] and serum transaminase levels [14]. Also an association to a higher risk of progression to cirrhosis in NAFLD patients has been shown [15]. Transaminase levels, particularly of alanine transaminase (ALT) and aspartate transaminase (AST), are strong indicators of hepatic steatosis [16] as well as of cardio-metabolic risks [17] and are associated with mortality even within their reference ranges [18]. Yet, a small number of studies reported gene-environment interactions for rs738409. Recently it has been shown that the G allele of rs738409 is associated with lower serum triglyceride and cholesterol levels and higher ALT levels in overweight individuals only [19]. Children with the minor G allele had more liver fat per unit omega-fat intake than major homozygous children [20]. In another study, sugar and carbohydrate intake in Hispanic children was positively related to hepatic fat fraction in GG carriers but not in CG and CC carriers [21].