Intravitreal conbercept injection for recurrent vitreous haemorrhage after diabetic vitrectomy

Abstract

Objective To assess the effects of intravitreal conbercept in treating delayed post-vitrectomy (4 weeks after surgery) diabetic vitreous hemorrhage (PVDVH). Methods Of 36 consecu-tive patients (36 eyes) with delayed PVDVH were assigned to tow groups, the study group (17 eyes) and the control group (19 eyes). The study group was treated with intravitreal conbercept, and repeated injection was given after 4 weeks in cases with no obvious blood absorption, until the blood was absorbed completely. The control group was given Chinese traditional medicine and iodized lecithin. The average follow-up duration was 8.5±2.5 months (ranged, 5~13 months). Results VCT of the study group was 2-8 weeks, mean 5.3±2.3 weeks, with average injection 2.2±0.8 times. Four eyes had developed recurrent vitreous hemorrhage (VH), but all of the eyes had a clear vitreous at the end of study period, and no vitrectomy surgery was needed. In the control group, eight eyes had spontaneous reabsorption in 3-9 weeks, mean 6.7±2.5 weeks, 11 eyes developed recurrent VH, the blood of one eye finally had been absorbed, 10 eyes had persistent VH, 4 eyes of them had iris neouvasculrization, and 4 eyes of them had retinal detachment, and finally these 10 eyes underwent revitrectomy surgeries. The vision of the study group was better than that in the control group. Conclusions Intravitreal conbercept treatment can accelerate the clear-up of the VH, reduce the complication and the need of revitrectomy for PVDVH. Key words: Conbercept; Diabetic retinopathy; Recurrent vitreous haemorrhage