Stability of Morphine Hydrochloride in a Total Parenteral Nutrient Solution

Abstract

The chemical stability of morphine hydrochloride in a total parenteral nutrient solution wasevaluated using a HPLC-ultraviolet detection system. This method is sensitive enough to measure morphine hydrochloride at concentrations as low as 0.2 nmol and produces highly reproducible results and requires 5.5 min per sample for separation and quantitation. Solutions of morphine hydrochloride in a total parenteral nutrient solution are chemically stable for 1 month when stored at 4°C and room temperature (20°C) with protection and no protection from environmental light. No loss of morphine hydrochloride due to adsorption in the polyethylene chloride (PEC) bags was found.