Infrared spectroscopy in detection of brain tumor of different morphological structure

Abstract

The study considers the results of application of blood serum infrared spectroscopy as a diagnosis method of brain tumors with various morphological structure. The study involves 99 patients with brain tumors (glioblastomas were diagnosed in 22 patients, astrocytomas – in 21, neuromas – in 13, meningiomas – in 12, ependymomas – in 11, oligodendroastrocytomas – in 10, hypophyseal adenomas – in 10 patients), 16 patients with acute cerebrovascular accidents of ischemic type, 24 patients with severe traumatic brain injury and 20 healthy volunteers. In each studied case, 13 ratios of peak heights of blood serum infrared spectrum absorption bands were studied applying infrared spectroscopy (IRS). The results of morphological and immunohistochemical examinations were compared with the results of blood serum IRS data of patients with brain tumors. There were statistically significant correlations between the histological nature of brain tumors and IRS values. Statistically significant differences between the blood serum IRS of patients with tumor, non-tumor brain lesions and healthy volunteers were also found.