{"title":"Strong Bones via Tailored Hormones","authors":"","doi":"10.1126/scisignal.1562002tw397","DOIUrl":null,"url":null,"abstract":"Interest in alternative preventive strategies against bone loss has intensified in light of the recent announcement of risks associated with hormone replacement therapy. Previous cell culture studies showed that estrogen and androgen protect bone through a mechanism distinct from the DNA-mediated mechanism underlying their effects on reproductive organs. Kousteni et al. now show that a synthetic compound (estren) that mimics these \"nongenotropic\" effects can increase bone mass in estrogen- or androgen-deficient mice without adverse effects on reproductive organs. S. Kousteni, J.-R. Chen, T. Bellido, L. Han, A. A. Ali, C. A. O'Brien, L. Plotkin, Q. Fu, A. T. Mancino, Y. Wen, A. M. Vertino, C. C. Powers, S. A. Stewart, R. Ebert, A. M. Parfitt, R. S. Weinstein, R. L. Jilka, S. C. Manolagas, Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298, 843-846 (2002). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"24 1","pages":"TW397 - tw397"},"PeriodicalIF":0.0000,"publicationDate":"2002-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1562002tw397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Interest in alternative preventive strategies against bone loss has intensified in light of the recent announcement of risks associated with hormone replacement therapy. Previous cell culture studies showed that estrogen and androgen protect bone through a mechanism distinct from the DNA-mediated mechanism underlying their effects on reproductive organs. Kousteni et al. now show that a synthetic compound (estren) that mimics these "nongenotropic" effects can increase bone mass in estrogen- or androgen-deficient mice without adverse effects on reproductive organs. S. Kousteni, J.-R. Chen, T. Bellido, L. Han, A. A. Ali, C. A. O'Brien, L. Plotkin, Q. Fu, A. T. Mancino, Y. Wen, A. M. Vertino, C. C. Powers, S. A. Stewart, R. Ebert, A. M. Parfitt, R. S. Weinstein, R. L. Jilka, S. C. Manolagas, Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 298, 843-846 (2002). [Abstract] [Full Text]
鉴于最近公布的激素替代疗法的相关风险，对骨质流失的替代预防策略的兴趣已经增强。先前的细胞培养研究表明，雌激素和雄激素通过一种不同于dna介导的机制保护骨骼，这是它们对生殖器官的影响。Kousteni等人现在表明，一种模拟这些“非基因致型”效应的合成化合物(estren)可以增加雌激素或雄激素缺乏小鼠的骨量，而不会对生殖器官产生不利影响。S. Kousteni, j.r。Chen, T. Bellido, L. Han, A. A. Ali, C. A. O'Brien, L. Plotkin, Q. Fu, A. T. Mancino, Y. Wen, A. M. Vertino, C. C. Powers, S. A. Stewart, R. Ebert, A. M. Parfitt, R. S. Weinstein, R. L. Jilka, S. C. Manolagas，性类固醇非基因性信号逆转小鼠骨质流失。科学298,843-846(2002)。【摘要】【全文】
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