Interleukin-6, a major player of cytokine storm in COVID-19 and its alleviation by therapeutic antibodies

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES Current Science Pub Date : 2022-09-25 DOI:10.18520/cs/v123/i6/745-753

Kumar Simant, Krishnan Venkataraman

引用次数: 0

Abstract

Interleukin-6 (IL-6) is an important cytokine that plays a vital role in immune response and inflamma-tion. Here, the signalling functions of IL-6 through its receptors, physiological and pathological roles, espe-cially its contribution to various autoimmune diseases, cancers and severe COVID-19/SARS-CoV2 infections are described. It is reported that in severe COVID-19 infection and auto-immune diseases, the patients expe-rience cytokine storms due to hyper-activation of the IL-6 receptor pathway leading to detrimental effects. Blocking IL-6 receptor action by therapeutic antibodies has been considered an attractive strategy of treat-ment. The latest findings on the application of anti-IL-6 therapeutic antibodies in COVID-19 patients are also discussed. © 2022,Current Science. All Rights Reserved.

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白细胞介素-6:COVID-19细胞因子风暴的主要参与者，并通过治疗性抗体减轻其影响

白细胞介素-6 (IL-6)是一种重要的细胞因子，在免疫反应和炎症中起着至关重要的作用。本文描述了IL-6通过受体的信号功能、生理和病理作用，特别是其在各种自身免疫性疾病、癌症和严重的COVID-19/SARS-CoV2感染中的作用。据报道，在严重的COVID-19感染和自身免疫性疾病中，由于IL-6受体途径的过度激活，患者会经历细胞因子风暴，从而产生不利影响。通过治疗性抗体阻断IL-6受体的作用被认为是一种有吸引力的治疗策略。并讨论了抗il -6治疗性抗体在COVID-19患者中的应用的最新发现。©2022,Current Science。版权所有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Science 综合性期刊-综合性期刊

CiteScore

1.50

自引率

10.00%

发文量

审稿时长

3 months

期刊介绍： Current Science, published every fortnight by the Association, in collaboration with the Indian Academy of Sciences, is the leading interdisciplinary science journal from India. It was started in 1932 by the then stalwarts of Indian science such as CV Raman, Birbal Sahni, Meghnad Saha, Martin Foster and S.S. Bhatnagar. In 2011, the journal completed one hundred volumes. The journal is intended as a medium for communication and discussion of important issues that concern science and scientific activities. Besides full length research articles and shorter research communications, the journal publishes review articles, scientific correspondence and commentaries, news and views, comments on recently published research papers, opinions on scientific activity, articles on universities, Indian laboratories and institutions, interviews with scientists, personal information, book reviews, etc. It is also a forum to discuss issues and problems faced by science and scientists and an effective medium of interaction among scientists in the country and abroad. Current Science is read by a large community of scientists and the circulation has been continuously going up. Current Science publishes special sections on diverse and topical themes of interest and this has served as a platform for the scientific fraternity to get their work acknowledged and highlighted. Some of the special sections that have been well received in the recent past include remote sensing, waves and symmetry, seismology in India, nanomaterials, AIDS, Alzheimer''s disease, molecular biology of ageing, cancer, cardiovascular diseases, Indian monsoon, water, transport, and mountain weather forecasting in India, to name a few. Contributions to these special issues ‘which receive widespread attention’ are from leading scientists in India and abroad.