Juliana G. de Morais, Clara S. C. Siqueira, Yasmine B. Queiroz, Vanessa C. S. Amaral, Luciana M. Ramos
{"title":"Synthetic and Biological Importance of Benzodiazepines: A Systematic Review","authors":"Juliana G. de Morais, Clara S. C. Siqueira, Yasmine B. Queiroz, Vanessa C. S. Amaral, Luciana M. Ramos","doi":"10.21577/1984-6835.20220107","DOIUrl":null,"url":null,"abstract":"Benzodiazepines (BZD) are heterocyclic compounds which stand out for their sedative, hypnotic, anxiolytic, and anticonvulsant activity. In order to develop more attractive syntheses based on literature data, this systematic review has analyzed the scientific articles on the synthesis and biological evaluation of benzodiazepine derivatives, application of catalysts, green solvents and strategic substitutions into this nucleus. A bibliographic research was performed in the Web of Science and PubMed databases and resulted in 522 articles. Among these, 80 of these articles met the inclusion criteria and were selected to compose this review. The structures that show better biological activity and the synthesis strategies to obtain these derivatives were reported. New perspectives in the synthesis of benzodiazepines were possible with this review.","PeriodicalId":21315,"journal":{"name":"Revista Virtual de Química","volume":"33 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Virtual de Química","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21577/1984-6835.20220107","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Benzodiazepines (BZD) are heterocyclic compounds which stand out for their sedative, hypnotic, anxiolytic, and anticonvulsant activity. In order to develop more attractive syntheses based on literature data, this systematic review has analyzed the scientific articles on the synthesis and biological evaluation of benzodiazepine derivatives, application of catalysts, green solvents and strategic substitutions into this nucleus. A bibliographic research was performed in the Web of Science and PubMed databases and resulted in 522 articles. Among these, 80 of these articles met the inclusion criteria and were selected to compose this review. The structures that show better biological activity and the synthesis strategies to obtain these derivatives were reported. New perspectives in the synthesis of benzodiazepines were possible with this review.
苯二氮卓类(BZD)是一种杂环化合物，具有镇静、催眠、抗焦虑和抗惊厥作用。为了在文献资料的基础上开发出更有吸引力的合成方法，本系统综述分析了苯二氮卓类衍生物的合成和生物学评价、催化剂的应用、绿色溶剂和策略取代等方面的科学文章。在Web of Science和PubMed数据库中进行了书目研究，结果得出522篇文章。其中80篇符合纳入标准，入选本综述。报道了具有较好生物活性的结构及其合成策略。本综述为苯二氮卓类化合物的合成开辟了新的前景。
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