C.B.E., M.D., M.C., F.R.C.S., F.F.R. Ralston Paterson, A.I.S., F.S.S. Marion H. Russell
{"title":"Clinical trials in malignant disease","authors":"C.B.E., M.D., M.C., F.R.C.S., F.F.R. Ralston Paterson, A.I.S., F.S.S. Marion H. Russell","doi":"10.1016/S0368-2242(59)80037-3","DOIUrl":null,"url":null,"abstract":"<div><p>The detailed results are given of a clinical trial to evaluate simple ovarian radiation (X-ray castration) for breast cancer. The over-all results at 3, 5, and 7 years show apparent advantage to ovarian radiation at statistical levels just short of the 1 : 20 conventional index. The findings for a large post-operative group randomly allocated shortly after operation are significant at conventional levels. A number of subgroups are studied without yielding any useful indications, as to the type of case most influenced. They do show, however, that the differences are demonstrable in stage 1 cases and in post-menopausal women. Analyses of the incidence of recurrences and metastases seem to suggest some degree of inhibition of these sequel˦ in the radiated cases.</p></div>","PeriodicalId":100844,"journal":{"name":"Journal of the Faculty of Radiologists","volume":"10 3","pages":"Pages 130-133"},"PeriodicalIF":0.0000,"publicationDate":"1959-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-2242(59)80037-3","citationCount":"71","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Faculty of Radiologists","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0368224259800373","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 71
Abstract
The detailed results are given of a clinical trial to evaluate simple ovarian radiation (X-ray castration) for breast cancer. The over-all results at 3, 5, and 7 years show apparent advantage to ovarian radiation at statistical levels just short of the 1 : 20 conventional index. The findings for a large post-operative group randomly allocated shortly after operation are significant at conventional levels. A number of subgroups are studied without yielding any useful indications, as to the type of case most influenced. They do show, however, that the differences are demonstrable in stage 1 cases and in post-menopausal women. Analyses of the incidence of recurrences and metastases seem to suggest some degree of inhibition of these sequel˦ in the radiated cases.