Autoimmiune Hepatitis in Children: Two Case Report

Benzamin, Zannatul Ferdous Sonia, Rukunuzzaman, K. Nahid, B. P. Dey, Kamal Hossen, K. Fathema, M. Khadga, M. Islam
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Abstract

Autoimmune hepatitis (AIH) is the disease of immune mediated in!ammation of liver. Presentation of AIH in children is variable, ranging from acute hepatitis to cirrhosis of liver and also as only asymptomatic raised ALT. AIH can present at any age and female are more a"ected. Here we are presenting two cases. Case 1 presented with jaundice and H/O epistaxis, having cutaneous echymosis, hepato-splenomegaly and ascites. Case 2 was a diagnosed case of Systemic Lupus Erythematosus (SLE) presented with only persistent raised of serum ALT. Both were diagnosed as autoimmune hepatitis on the basis of positive auto antibodies, histopathology of liver tissues and exclusion of all other causes of acute and chronic hepatitis.
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儿童自身免疫性肝炎2例报告
自身免疫性肝炎(AIH)是一种免疫介导的疾病。肝脏损伤。AIH在儿童中的表现是多种多样的,从急性肝炎到肝硬化,也只有无症状的ALT升高。AIH可以出现在任何年龄,女性更常见。这里我们提出两个案例。病例1表现为黄疸和H/O型鼻出血,伴有皮肤瘀肿、肝脾肿大和腹水。病例2诊断为系统性红斑狼疮(SLE),仅表现为血清ALT持续升高。根据自身抗体阳性、肝组织病理检查及排除所有其他引起急慢性肝炎的原因,诊断为自身免疫性肝炎。
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