Evaluation of Choroidal Thickness Changes in Euthyroid Graves’ Ophthalmopathy

IF 0.2 Q4 ENDOCRINOLOGY & METABOLISM Turkish Journal of Endocrinology and Metabolism Pub Date : 2018-01-01 DOI:10.25179/tjem.20182202-p129
E. Cagiltay, F. Akay
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Abstract

Objective: Clinical manifestations of GO are caused by the over compression of orbital tissues within the restricted orbital bone cavity. Impaired ocular blood flow may disrupt the retinal microstructure and functions.. In this study we aimed to investigate the macular and choroidal thickness changes in GO compared with healthy subjects. Materials and Methods: The study group comprised 50 adult patients with previously diagnosed Graves’ Disease with ophthalmopathy who were on anti-thyroid treatment. For the assessment of GO activity. VISA (vision. inflammation. strabismus. and appearance) inflammatory score was used. When euthryoidism was achieved without side effects. the patients were referred to the ophthalmology clinic for Spectraldomain optical coherence tomography (SD-OCT) evaluation. Results: Subfoveal. mean and temporal choroidal thicknesses were increased significantly in study group according to the controls. The mean choroidal thickness was elevated. Conclusions: This elevation is because of the retroorbital inflammation even in this non-severe GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure.
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甲状腺功能正常的Graves眼病脉络膜厚度变化的评价
目的:氧化石墨烯的临床表现是由于受限眶骨腔内眶组织过度受压所致。眼血流受损可能会破坏视网膜的微观结构和功能。在本研究中,我们旨在研究氧化石墨烯与健康受试者相比黄斑和脉络膜厚度的变化。材料和方法:研究组包括50例既往诊断为Graves病合并眼病并接受抗甲状腺治疗的成年患者。用于评价氧化石墨烯活性。签证(愿景。炎症。斜视。采用外观炎症评分法。当甲状腺功能恢复正常且无副作用时。转至眼科门诊进行光谱域光学相干断层扫描(SD-OCT)评估。结果:Subfoveal。与对照组相比,研究组的平均脉络膜厚度和颞部脉络膜厚度均显著增加。脉络膜平均厚度增高。结论:即使在非严重氧化石墨烯组中,这种升高也是由于眶后炎症。GO患者静脉阻塞和充血可能影响脉络膜厚度。脉络膜厚度的升高可能是发生在眼压升高之前的静脉充血的早期征兆。
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来源期刊
CiteScore
0.50
自引率
0.00%
发文量
7
审稿时长
8 weeks
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