{"title":"Natalizumab related progressive multifocal leukoencephalopathy","authors":"Lana Zhovtis Ryerson , Eugene O. Major","doi":"10.1016/j.ddmod.2020.02.002","DOIUrl":null,"url":null,"abstract":"<div><p>Progressive multifocal leukoencephalopathy<span><span> (PML), is an opportunistic brain infection that is caused by the JC virus. It usually occurs in patients with an underlying disease and therapies used to treat such diseases that inhibit normal immune system function. For example, </span>multiple sclerosis<span> patients treated with natalizumab have been identified at risk for PML. This serious adverse event has been very instructive in improving understanding of PML pathogenesis, biomarkers and patient management with this disease in recent years.</span></span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2020.02.002","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675720300049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
Progressive multifocal leukoencephalopathy (PML), is an opportunistic brain infection that is caused by the JC virus. It usually occurs in patients with an underlying disease and therapies used to treat such diseases that inhibit normal immune system function. For example, multiple sclerosis patients treated with natalizumab have been identified at risk for PML. This serious adverse event has been very instructive in improving understanding of PML pathogenesis, biomarkers and patient management with this disease in recent years.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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