Late Onset Mania after the Removal of Right Anterior Temporal Lobe Oligodendroglioma

Abstract

The pathogenesis of bipolar disorder is multi-factorial and not fully understood, having polygenetic inheritance which may cause changes in neurotransmitter systems and dysfunction of fronto-limbic neuronal circuits. We aim to present a case which supports the hypothesis that right hemispheric hypofunctioning may contribute to the pathogenesis of bipolar disorder. Our manuscript includes a case of a 62-year-old male with new onset mania following resection of right sided temporal oligodendroglioma, suggesting that the hypofunctioning of this hemisphere may have lead to increased blood flow and activation of the left hemisphere.