{"title":"Control of luteal function during early pregnancy in sheep.","authors":"J. Martal","doi":"10.1530/BIOSCIPROCS.1.019","DOIUrl":null,"url":null,"abstract":"Prolactin and LH are required for the maintenance of normal luteal structures during early pregnancy in the ewe, whilst luteolysis, induced by prostaglandin F-2 alpha is inhibited by the presence of the conceptus. The trophoblast also secretes a local anti-luteolytic factor, trophoblastin, which is most probably a protein because it is thermolabile and inactivated by pronase. It is soluble at pH 9.6 and can be separated on Ultrogel. Trophoblastin is present for a short time (12th-22nd day of pregnancy) but its effect may last several months.","PeriodicalId":16956,"journal":{"name":"Journal of reproduction and fertility. Supplement","volume":"22 1","pages":"201-10"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of reproduction and fertility. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/BIOSCIPROCS.1.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16
Abstract
Prolactin and LH are required for the maintenance of normal luteal structures during early pregnancy in the ewe, whilst luteolysis, induced by prostaglandin F-2 alpha is inhibited by the presence of the conceptus. The trophoblast also secretes a local anti-luteolytic factor, trophoblastin, which is most probably a protein because it is thermolabile and inactivated by pronase. It is soluble at pH 9.6 and can be separated on Ultrogel. Trophoblastin is present for a short time (12th-22nd day of pregnancy) but its effect may last several months.
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