Reproducing patient-specific 3D-model of pulmonary artery hemodynamics by means of in vitro benchtop simulation

Sanket Shah, Natalie Behrle, M. Salek, Masoud Farahmand, Anmol Goyal, A. Divekar, Ethan O. Kung
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Abstract

Aim: Patient-specific fluid dynamic simulation of pulmonary arteries can be a valuable tool in pre-procedural planning. Materials & methods: For three patients, soft, deformable models of the pulmonary arteries were 3D printed from cardiac magnetic resonance data. In vitro hemodynamics were replicated using a gear flow pump, 40% glycerol solution and a physical Windkessel module. The pulmonary pressures were compared with patient cardiac catheterization pressure. Results: The pulmonary artery pressures and flow volumes had an adequate goodness of fit except for pulmonary pressures in patient 2. Conclusion: Cardiac magnetic resonance angiogram and flow volume data can be leveraged to generate a patient-specific 3D model and reproduce in vivo hemodynamics by means of in vitro simulation.
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采用体外台式模拟的方法重建患者肺动脉血流动力学三维模型
目的:患者肺动脉流体动力学模拟可作为术前规划的重要工具。材料与方法:对3例患者,根据心脏磁共振数据3D打印出柔软、可变形的肺动脉模型。使用齿轮流泵、40%甘油溶液和物理Windkessel模块复制体外血流动力学。将肺动脉压与患者心导管插管压进行比较。结果:除2例患者肺动脉压外,肺动脉压和肺动脉流量的拟合优度均较好。结论:利用心脏磁共振血管造影和血流容量数据可以生成患者特异性的三维模型,并通过体外模拟再现体内血流动力学。
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