Recent progress in encapsulation and controlled release of pesticides based on cyclodextrin derivative carriers

Zhisheng Liu , Weiwei Xu , Elena G. Kovaleva , Jing Cheng , Haibing Li
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引用次数: 3

Abstract

In the context of the continuous increase in global grain production, accompanied by a large amount of investment in various pesticides, herbicides, fungicides, and other chemical pesticides. It has caused inevitable environmental problems and food safety problems. Current research suggests that the use of cyclodextrins and their derivatives to protect pesticides can significantly reduce the number of agrochemicals that pollute the environment. Using the cavity properties of cyclodextrins, we can refer to the similar way in which drug molecules make cyclodextrins and cyclodextrin polymers to form inclusion compounds. Overall, β-cyclodextrin and its derivatives are used as a new pesticide excipient to improve the stability of pesticides, prevent their oxidation and decomposition, improve the solubility and bioavailability of pesticides, reduce the toxic side effects of drugs, and mask the odour of drugs. In this review, we focus on summarising the recent research progress of β-cyclodextrins and their derivatives in pesticides and other fields, and provide a systematic classification of β-cyclodextrin polymers, as well as new synthesis methods and techniques in various applications. Finally, the future development of cyclodextrin-like polymers is foreseen, and issues arising from the research are discussed and addressed in depth.

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环糊精衍生物载体农药包封控释研究进展
在全球粮食产量不断增加的背景下,伴随着各种农药、除草剂、杀菌剂和其他化学农药的大量投资。造成了不可避免的环境问题和食品安全问题。目前的研究表明,使用环糊精及其衍生物来保护农药可以显著减少污染环境的农用化学品的数量。利用环糊精的空腔特性,我们可以参考药物分子使环糊精和环糊精聚合物形成包合化合物的类似方法。总的来说,β-环糊精及其衍生物作为一种新型的农药辅料,可以提高农药的稳定性,防止农药的氧化分解,提高农药的溶解度和生物利用度,减少药物的毒副作用,掩盖药物的气味。本文综述了近年来β-环糊精及其衍生物在农药等领域的研究进展,对β-环糊精聚合物进行了系统的分类,并对其在各种应用中的新合成方法和技术进行了综述。最后,对环糊精类聚合物的未来发展进行了展望,并对研究中出现的问题进行了深入的讨论和解决。
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