Targeting Inflammation to Control Tissue Fibrosis

Weihua Song, Wu Sun, Zilong Wang, K. Teo, C. Cheung, Xiaomeng Wang
{"title":"Targeting Inflammation to Control Tissue Fibrosis","authors":"Weihua Song, Wu Sun, Zilong Wang, K. Teo, C. Cheung, Xiaomeng Wang","doi":"10.53941/ijddp.v1i1.206","DOIUrl":null,"url":null,"abstract":"Review\nTargeting Inflammation to Control Tissue Fibrosis\n\nWeihua Song 1, Wu Sun 2, Zilong Wang 3, Kelvin Yi Chong Teo 2,4,5, Chui Ming Gemmy Cheung 2,4,5, and Xiaomeng Wang 4,5,6,*\n\n\n1 Innoland Biosciences, 6 West Beijing Road, Taicang 215400, Jiangsu, China.\n2 Singapore National Eye Center, 11 Third Hospital Ave 168751, Singapore.\n3 Ocean University of China, 5 Yushan Rd, Shinan District, Qingdao 266005, Shandong, China.\n4 Singapore Eye Research Institute, 20 College Road 169856, Singapore.\n5 Duke-NUS Graduate Medical School, 20 College Road 169856, Singapore.\n6 Insitute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos 138673, Singapore.\n* Correspondence: xiaomeng.wang@duke-nus.edu.sg\n \n \nReceived: 17 November 2022\nAccepted: 19 November 2022\nPublished: 21 December 2022\n \n\nAbstract: Remodeling of the extracellular matrix (ECM) is an essential process in host defense against pathogens and tissue repair following injury. However, aberrant inflammatory responses could disturb ECM homeostasis leading to progressive disruption in tissue architecture and organ function. Fibrosis is the common outcome of a wide range of diseases, especially chronic inflammatory disorders, and represents the leading cause of morbidity and mortality globally. This review provides the current understanding of the pathogenesis of fibrosis, with particular emphasis on the role of inflammation in this process and the translational potential of targeting inflammation as a strategy to control fibrotic progression.","PeriodicalId":94047,"journal":{"name":"International journal of drug discovery and pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of drug discovery and pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53941/ijddp.v1i1.206","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Review Targeting Inflammation to Control Tissue Fibrosis Weihua Song 1, Wu Sun 2, Zilong Wang 3, Kelvin Yi Chong Teo 2,4,5, Chui Ming Gemmy Cheung 2,4,5, and Xiaomeng Wang 4,5,6,* 1 Innoland Biosciences, 6 West Beijing Road, Taicang 215400, Jiangsu, China. 2 Singapore National Eye Center, 11 Third Hospital Ave 168751, Singapore. 3 Ocean University of China, 5 Yushan Rd, Shinan District, Qingdao 266005, Shandong, China. 4 Singapore Eye Research Institute, 20 College Road 169856, Singapore. 5 Duke-NUS Graduate Medical School, 20 College Road 169856, Singapore. 6 Insitute of Molecular and Cell Biology, 61 Biopolis Dr, Proteos 138673, Singapore. * Correspondence: xiaomeng.wang@duke-nus.edu.sg     Received: 17 November 2022 Accepted: 19 November 2022 Published: 21 December 2022   Abstract: Remodeling of the extracellular matrix (ECM) is an essential process in host defense against pathogens and tissue repair following injury. However, aberrant inflammatory responses could disturb ECM homeostasis leading to progressive disruption in tissue architecture and organ function. Fibrosis is the common outcome of a wide range of diseases, especially chronic inflammatory disorders, and represents the leading cause of morbidity and mortality globally. This review provides the current understanding of the pathogenesis of fibrosis, with particular emphasis on the role of inflammation in this process and the translational potential of targeting inflammation as a strategy to control fibrotic progression.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
靶向炎症控制组织纤维化
综述:靶向炎症控制组织纤维化宋卫华1,孙武2,王子龙3,易创创2,4,5,张翠明2,4,5,王晓梦4,5,*1创兰生物科技有限公司,江苏太仓215400北京西路6号;2新加坡国立眼科中心,新加坡第三医院大道168751号;3中国海洋大学,山东青岛市市南区玉山路5号;4新加坡眼科研究所,学院路169856号;5 Duke-NUS研究生医学院,20 College Road 169856,新加坡。6分子与细胞生物学研究所,61 Biopolis Dr, Proteos 138673,新加坡。摘要:细胞外基质(extracellular matrix, ECM)的重塑是宿主防御病原体和损伤后组织修复的重要过程。然而,异常的炎症反应可能会扰乱ECM稳态,导致组织结构和器官功能的进行性破坏。纤维化是多种疾病,特别是慢性炎症性疾病的常见结果,是全球发病率和死亡率的主要原因。这篇综述提供了目前对纤维化发病机制的理解,特别强调炎症在这一过程中的作用,以及靶向炎症作为控制纤维化进展策略的转化潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Inhibiting the Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Cascade in Cancer and the Heart: for Better or Worse, in Sickness and Health? Breaking Boundaries: Novel Effects of Levosimendan in Various Diseases Development of Proteasome Inhibitors for Cancer Therapy Mkk7 Protects Against Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction Transforming Growth Factor β Signaling Pathway as a Potential Drug Target in Treating Aortic Diseases
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1