Bert A. ‘t Hart , Che Serguera , Yolanda S. Kap , Bruno Gran
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引用次数: 0
Abstract
Ageing Western societies are facing an increasing prevalence of chronic inflammatory and degenerative diseases for which no effective treatments exist. The pressure on the drug development industry to develop such treatments creates a need for translationally relevant animal models, which faithfully replicate essential pathogenic mechanisms of the human disease. In this Short Review, we discuss the essential role of the non-human primate (NHP) in the translational research into the pathogenesis and treatment of the autoimmune neurological disease multiple sclerosis (MS).
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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