Carcinogen Switching NQO1 Gene Polymorphism Study to Find Out the Risk Population in Vindhyan Region

Abstract

The NQO1 is an important carcinogen metabolizing gene, as responsible for the metabolism of highly ubiquitous environmental carcinogen like Polycyclic Aromatic Hydrocarbon (PAH) which is also the most lethal constituent of cigarette smoke. The genotype and allelic frequencies of three Polycyclic aromatic Hydrocarbon (PAH) metabolizing genes were determined in a sample of typical population, which were stratified into three groups (Hindu, Muslim and Tribal) based on their ethnicity. DTdiphorase is an enzyme which has known because of its ability to detoxify a number of natural and Synthetic Compounds and also to activate certain anticancer factors [1]. Among Northern Europeans and Caucasian Americans, the gene frequency is 0.79 for the wild-type allele and 0.21 for the mutated allele [2,3]. DT-diphorase (NQO1) converts toxic benzoquinone into hydroquinone in an obligate two electron reduction [4].