Amerolative Influence of Chamomile (Matricaria recutita L.) on Synthetic Food Additive Induced Probable Toxicity in Male Albino Rats التأثير المخفف للبابونج علي السمية المحتملة للمضافات الغذائية الصناعية في ذکور الجرذان البيضاء

Abstract

This study was carried out to evaluate the effect of chamomile as a natural product to reduce the negative effects of some food additives. Evaluation of the toxic effects of monosodium glutamate, Sunset Yellow (E110) and Synthetic Dye Brilliant Blue (SDBB) were tested in 45 male albino rats weighing 150-180g b.wt each, and divided into 9 equal groups, first was kept as a control-ve group, while group 2,3,4,5 were control+ve given Monosodium glutamate (MSG) (70 g/kg), Sunset Yellow (E110) 2g/kg bw ), and Synthetic Dye Brilliant Blue (SDBB) 2g/kg b.wt respectively daily for 56 days. Other groups were treated with (MSG), E110, SDBB, plus tested chamomile. Chamomile (Matricaria recutita L.) is given as a percent of 5% from the basal diet. then measuring their actions on liver function, kidney function, cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, VLDL cholesterol , atherogenic index (AI), Malondialdehyde (MDA), Superoxide dismutase activity (SOD), (CAT) catalase and reduced glutathione GSH, and histopathological changes of liver and brain were examined. The results found that feeding with chamomile improved lipids profile and antioxidant enzymes backed to normal levels. Also, according to our results, chamomile could be used for improving liver and kidney functions. Conclusion: it could be concluded that Chamomile offers a therapeutic advantage that minimizes the metabolic abnormalities and biochemical changes induced by these food additives. Also, food additives (MSG) and synthetic colorants administration should not be used for a large amounts or long period in a human’s diet.