{"title":"Sex differences in the epigenetic regulation of chronic visceral pain following unpredictable early life stress","authors":"T. Louwies, B. Greenwood-Van Meerveld","doi":"10.1111/nmo.13751","DOIUrl":null,"url":null,"abstract":"We previously reported that early life stress (ELS) dysregulated glucocorticoid receptor (GR) and corticotrophin‐releasing hormone (CRH) expression in the central nucleus of the amygdala (CeA). Epigenetic modifications serve as memories of adverse events that occurred during early life. Therefore, we hypothesized that epigenetic mechanisms alter GR and CRH expression in the CeA and underlie chronic visceral pain after ELS.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"132 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogastroenterology & Motility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/nmo.13751","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
We previously reported that early life stress (ELS) dysregulated glucocorticoid receptor (GR) and corticotrophin‐releasing hormone (CRH) expression in the central nucleus of the amygdala (CeA). Epigenetic modifications serve as memories of adverse events that occurred during early life. Therefore, we hypothesized that epigenetic mechanisms alter GR and CRH expression in the CeA and underlie chronic visceral pain after ELS.
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