In vivo effects of phenolic compounds on blood parameters of a marine fish (Dicentrarchus labrax)

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology Pub Date : 2000-03-01 DOI:10.1016/S0742-8413(99)00119-X

Hélène Roche , Gérard Bogé

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引用次数: 48

Abstract

Sea bass (Dicentrarchus labrax) were injected intraperitoneally once (single dose) or three times (fractionated dose) with phenol or OH-phenols (hydroquinone, resorcinol, and pyrocatechol). On the basis of the lethal doses, OH-phenols were more toxic than phenol, and pyrocatechol was the most powerful compound. Hematological, metabolic and antioxidant blood parameters were measured 3 days after the end of the treatment. Metabolic variations as specific effects on erythrocytes were revealed and differences between single and fractionated doses were observed. OH-phenols-treated fish showed disorders in the metabolic toxicity indicators as hypoglycemia, low blood urea nitrogen level (BUN) and decrease of alkaline phosphatase activity (ALP). In addition, quantitative structure-activity relationships were developed using the n-octanol:water partition coefficient (log K_ow). Positive correlations were found with ALP, plasma glucose and hemoglobin.

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酚类化合物对海鱼血液参数的体内影响

将苯酚或oh -酚类物质(对苯二酚、间苯二酚和邻苯二酚)腹腔注射1次(单次)或3次(分次)。从致死剂量来看，oh -酚的毒性大于苯酚，邻苯二酚的毒性最强。治疗结束后3 d测定血液学、代谢和抗氧化血液参数。代谢变化作为对红细胞的特定影响被揭示，并观察到单剂量和分剂量之间的差异。oh -酚处理后的鱼出现低血糖、低尿素氮(BUN)和碱性磷酸酶活性(ALP)等代谢毒性指标紊乱。此外，利用正辛醇:水分配系数(log Kow)建立了定量构效关系。与ALP、血糖、血红蛋白呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology

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