Modeling and assaying seizure activity in zebrafish (Danio rerio)

Abstract

Epilepsy is a common neurological disease that has many causes with unclear pathophysiological mechanisms. Epilepsy, commonly studied in rodents, can also be modeled in zebrafish (Danio rerio). There are effective pharmacological and genetic models for zebrafish, sensitive to both pro and anticonvulsant effects. These aquatic models are likely to help expand the fundamental knowledge about the mechanisms of epilepsy pathogenesis and develop epilepsy therapy.