Preparation of Ethanolamine Oleate Injection Mixed with Iopamidol

Abstract

(Received February 17,1988) Ethanolamine oleate injection containing 30% iopamiron 300 (30% IP 300-E0) has been previously prepared for endoscopic sclerotherapy of esophageal varices on X-ray TV monitor. However,the ability of fluoroscopic visualization of this sclerosing agent was slightly insufficient in clinical use.We prepared ethanolamine oleate injection containing 30% iopamiron 370 (30% IP 370-E0),and measured the physical characteristics such as viscosity and osmotic pressure of this agent.The ability of visualization was observed in patients with esophageal varix by X-ray. The viscosity,which was inversely related to the injectability into varices,of 30% IP 370-E0 was relatively low and its osmotic nressure was almost the same as that of normal saline.30 % IP 370-E0 was easily injected into varices.Better fluoroscopic visualization was obtained by intravariceal injection with 30% IP 370-E0 than with 30% IP 300-E0.These results suggest that 30% 1P370-E0 is more useful agent for endoscopic sclerotherapy of esophageal varices.