The effect of charantin on expression of Ngn3 gene in streptozotocin-induced diabetic rats

Abstract

Background: Positive effects of medicinal herbs on diabetes have been demonstrated in previous studies. The aim of the present study was to evaluate the effect of charantin on the treatment of diabetes and increase the expression of the Ngn3 gene in diabetes, which is a key gene for transcription of the pancreas. Materials and methods: In this experimental study, 42 adult male Wistar rats were randomly divided into 7 healthy control groups, diabetic control, control group, 150 control, and three groups receiving effective doses of charantin (50-100-200 mg/ Per kilogram). All groups except diabetic control group and control group with streptozotocin chemical injected intraperitoneally. Afterwards, they received a cartilage by gavage for four weeks (three times a week). Results: The lowest expression was observed in the diabetic group. Among those who received different doses of charantine, the highest expression was among group with dose of 100 mg/kg, and the lowest expression in 50/kg group. Conclusion: It can be concluded that increased expression of the Ngn3 gene was not dose-dependent. After the development of diabetes, the patient's severity declined sharply, and after the use of the charantin and metformin drug, this reduction was somewhat offset.