Estrogen, progesterone, and androgen receptor expression in levator ani muscle and fascia.

P. Copas, A. Bukovsky, A. Bukovsky, Bridgett Asbury, R. Elder, M. Caudle
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引用次数: 94

Abstract

Previous studies have reported controversial data on estrogen receptor (ER) expression in levator ani muscle. We investigated ER expression in levator ani muscle and fascia and compared it with the expression of progesterone receptor (PR) and androgen receptor (AR). The study included 55 women undergoing surgery for gynecological (asymptomatic, n = 10) or urogynecological conditions (symptomatic, n = 45). The asymptomatic and 21 of the symptomatic women received no hormone replacement therapy (HRT). The remaining 24 symptomatic women received some form of HRT. Biopsies were taken from the levator ani muscle and the overlying fascia, and quantitative measurements of immunohistochemical staining by image analysis were made. None of the levator ani muscle samples showed any evidence of nuclear ER expression in striated muscle fibers, but some cells in the muscular stroma did express ER. However, PR and AR expression was found in both muscle and stromal cells. Levator ani fascia showed nuclear ER, PR, and AR expression to varying degrees. There was a significant increase (p < 0.03) in ER expression in levator ani fascia of symptomatic patients without HRT when compared with asymptomatic age-matched women. The ER expression was significantly lower (p < 0.001) in postmenopausal symptomatic women receiving long-term estrogen replacement compared with age-matched women without HRT. Our data indicate that ER expression is significantly higher in symptomatic women compared with age-matched asymptomatic females. However, long-term estrogenization causes significant decrease of ER expression.
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提肛肌和筋膜中雌激素、孕激素和雄激素受体的表达。
以往的研究报道了有争议的雌激素受体(ER)在提肛肌中的表达数据。我们研究了ER在提肛肌和筋膜中的表达,并将其与孕激素受体(PR)和雄激素受体(AR)的表达进行了比较。该研究包括55名因妇科(无症状,n = 10)或泌尿妇科(有症状,n = 45)接受手术的女性。无症状和有症状的21名妇女未接受激素替代治疗(HRT)。其余24名有症状的妇女接受了某种形式的激素替代疗法。从提肛肌和上覆筋膜取活检,通过图像分析进行免疫组化染色定量测量。提肛肌样本在横纹肌纤维中没有核ER表达的证据,但肌肉基质中的一些细胞确实表达ER。然而,PR和AR在肌肉和基质细胞中均有表达。提肛筋膜有不同程度的核ER、PR、AR表达。无HRT的有症状的提肛肌筋膜ER表达明显高于无症状的同龄女性(p < 0.03)。绝经后有症状的接受长期雌激素替代的妇女与未接受激素替代的同龄妇女相比,ER表达显著降低(p < 0.001)。我们的数据表明,与年龄匹配的无症状女性相比,有症状女性的ER表达明显更高。然而,长期雌激素治疗导致ER表达明显降低。
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