Deepak Choudhary, B. Mahajan, M. Sumi, Binita Dholakia, Sumit Bhandari, Niraj R. Ghimire, S. Saluja, Shaam Bodeliwala, W. Wani, A. Jagetia
{"title":"Polymorphism of XRCC7 Gene and Risk of Glioma: A Prospective Case–Control Study","authors":"Deepak Choudhary, B. Mahajan, M. Sumi, Binita Dholakia, Sumit Bhandari, Niraj R. Ghimire, S. Saluja, Shaam Bodeliwala, W. Wani, A. Jagetia","doi":"10.1055/s-0043-1771213","DOIUrl":null,"url":null,"abstract":"Abstract Objective The aim of this study is to determine association between polymorphism of XRCC7 gene and glioma. Materials and Methods A case–control study was designed to analyze the prevalence of the various XRCC7 genotypes in 30 cases of histologically proven glioma and 30 age- and sex matched controls. Result There is significantly higher prevalence of the GT and the TT genotypes of XRCC7 gene in cases of glioma as compared with control. The prevalence was significantly pronounced in two subgroups–middle aged and male gender. The presence of the XRCC7 GT or TT genotype conferred a significantly higher risk of developing glioma (odds ratio: 13.021,2.114–80.213). Conclusion The presence of the T allele in XRCC7 polymorphism may increase the susceptibility to glioma.","PeriodicalId":53938,"journal":{"name":"Indian Journal of Neurosurgery","volume":"67 1","pages":"168 - 173"},"PeriodicalIF":0.3000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Neurosurgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0043-1771213","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 1
Abstract
Abstract Objective The aim of this study is to determine association between polymorphism of XRCC7 gene and glioma. Materials and Methods A case–control study was designed to analyze the prevalence of the various XRCC7 genotypes in 30 cases of histologically proven glioma and 30 age- and sex matched controls. Result There is significantly higher prevalence of the GT and the TT genotypes of XRCC7 gene in cases of glioma as compared with control. The prevalence was significantly pronounced in two subgroups–middle aged and male gender. The presence of the XRCC7 GT or TT genotype conferred a significantly higher risk of developing glioma (odds ratio: 13.021,2.114–80.213). Conclusion The presence of the T allele in XRCC7 polymorphism may increase the susceptibility to glioma.
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