Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice

L. Basso, Mehdi Benamar, Xavier Mas-Orea, C. Deraison, C. Blanpied, N. Cenac, A. Saoudi, G. Dietrich
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引用次数: 13

Abstract

The opioid‐mediated analgesic activity of mucosal CD4+ T lymphocytes in colitis has been reported in immunocompetent mice so far. Here, we investigated whether CD4+ T lymphocytes alleviate from inflammation‐induced abdominal pain in mice with defective immune regulation.
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IL - 10缺失小鼠中T细胞源性阿片类药物内源性控制炎性内脏疼痛
阿片介导的粘膜CD4+ T淋巴细胞在结肠炎中的镇痛活性在免疫功能正常的小鼠中已有报道。在这里,我们研究了CD4+ T淋巴细胞是否减轻免疫调节缺陷小鼠炎症诱导的腹痛。
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