The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor

Abstract

Background and Objectives Continuous exercise with moderate intensity and the use of nanocurcumin supplementation has the potential to control and reduce tumors of the central nervous system, including glioblastoma. We assessed the simultaneous effect of moderate-intensity continuous exercises and nanocurcumin supplementation on STAT3 gene expression in mice with glioblastoma multiforme brain tumors. Subjects and Methods Thirty-five male Wistar rats were randomly divided into seven groups of five rats: basal control (BC), 4-week control (4wC), basal cancer control (BT), 4-week cancer control (4 wT), cancer+training (TE), cancer+nanocurcumin (TN), cancer+ exercise + nanocurcumin (TEN). After injection of cancer cells in the forehead, the animals were treated with nanocurcumin by gavage at the dose of 80 mg/kg for 28 days, five days a week, and started moderate-intensity continuous training on the treadmill for four weeks, three days/weeks, 25 to 40 minutes per week at a speed of 18 m/min. Finally, and then rats were sacrificed and data were collected. Results Moderate-intensity continuous training with nanocurcumin supplementation significantly reduced tumor volume and STAT3 gene expression in the TEN group (P<0.05). But this decrease was not significant in the TE and TN groups. Conclusion It seems that with decreased STAT3 gene expression and brain tumor size, the combination of moderate-intensity continuous training and nanocurcumin supplementation has a therapeutic role in the treatment process of glioblastoma multiforme brain tumors.