Microencapsulation of enriched extracts of two Satureja species by spray drying, evaluation of the controlled release mechanism and cytotoxicity

Q4 Pharmacology, Toxicology and Pharmaceutics Infarma Pharmaceutical Sciences Pub Date : 2021-09-05 DOI:10.34172/ps.2021.54
F. Fathi, S. Nejad Ebrahimi, D. Pereira, B. Estevinho, F. Rocha
{"title":"Microencapsulation of enriched extracts of two Satureja species by spray drying, evaluation of the controlled release mechanism and cytotoxicity","authors":"F. Fathi, S. Nejad Ebrahimi, D. Pereira, B. Estevinho, F. Rocha","doi":"10.34172/ps.2021.54","DOIUrl":null,"url":null,"abstract":"Background: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Method: The phenolic compounds of Satureja khuzistanica Jamzad (SKH) and S. rechingeri Jamzad (SRH) were enriched based on adsorbent resin column chromatography and the enrichment index was confirmed by HPLC-UV analysis. Gum Arabic, carboxylated chitosan, and pectin with the optimum percentage of 1% w/w used to encapsulate SKH and SRH by the spray drying technique. Result: Encapsulation yield was 38.18 – 59.00 %, particle size ranged 2.278 - 4.689 µm, and release time was between 4.08 - 82.08 min. The gum Arabic-based capsules showed the fastest and pectin-based revealed the slowest release time. The best statistical model explained a release mechanism was Korsmeyer model. Anomalous transport was observed from all formulas except SKH-gum Arabic (case-I transport), SKH-pectin, and SRH-carboxylated-chitosan (super case-II transport). The cytotoxic activity of encapsulate SKH’s revealed reducing the viability of AGS evaluated by the MTT compared with SRH’s. Conclusion: Encapsulation by spray drying has proven to be a promising technique to improve the bioavailability, release time, and mechanism of functional polyphenolic compounds as medicines, food supplements, and food additives.","PeriodicalId":31004,"journal":{"name":"Infarma Pharmaceutical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infarma Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/ps.2021.54","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 3

Abstract

Background: Phenolic compounds are one of the main groups of secondary metabolites responsible for multiple biological and pharmacological properties that play a vital role in improving human health quality. Encapsulation by spray dryer creates protection toward the phenolic compounds as an efficient way for increasing product performance. Method: The phenolic compounds of Satureja khuzistanica Jamzad (SKH) and S. rechingeri Jamzad (SRH) were enriched based on adsorbent resin column chromatography and the enrichment index was confirmed by HPLC-UV analysis. Gum Arabic, carboxylated chitosan, and pectin with the optimum percentage of 1% w/w used to encapsulate SKH and SRH by the spray drying technique. Result: Encapsulation yield was 38.18 – 59.00 %, particle size ranged 2.278 - 4.689 µm, and release time was between 4.08 - 82.08 min. The gum Arabic-based capsules showed the fastest and pectin-based revealed the slowest release time. The best statistical model explained a release mechanism was Korsmeyer model. Anomalous transport was observed from all formulas except SKH-gum Arabic (case-I transport), SKH-pectin, and SRH-carboxylated-chitosan (super case-II transport). The cytotoxic activity of encapsulate SKH’s revealed reducing the viability of AGS evaluated by the MTT compared with SRH’s. Conclusion: Encapsulation by spray drying has proven to be a promising technique to improve the bioavailability, release time, and mechanism of functional polyphenolic compounds as medicines, food supplements, and food additives.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
喷雾干燥制备两种红柳提取物的微胶囊化、控释机制及细胞毒性评价
背景:酚类化合物是次生代谢产物的主要类群之一,具有多种生物学和药理学特性,在提高人体健康质量方面发挥着重要作用。喷雾干燥机的封装对酚类化合物产生保护,是提高产品性能的有效方法。方法:采用吸附树脂柱层析法对胡兹stanica Jamzad (SKH)和S. rechingeri Jamzad (SRH)中的酚类化合物进行富集,并采用HPLC-UV分析确定富集指数。采用喷雾干燥技术,以阿拉伯胶、羧化壳聚糖和果胶的最佳包封量为1% w/w,包封SKH和SRH。结果:包封率为38.18% ~ 59.00%,粒径为2.278 ~ 4.689µm,释药时间为4.08 ~ 82.08 min,以阿拉伯胶为基的胶囊释药速度最快,以果胶为基的释药速度最慢。最能解释释放机制的统计模型是Korsmeyer模型。除skh -阿拉伯胶(case-I转运)、skh -果胶和srh -羧化壳聚糖(超级case-II转运)外,所有配方均观察到异常转运。与SRH相比,包封SKH的细胞毒活性显示MTT评估的AGS活力降低。结论:喷雾干燥包封技术在提高功能性多酚类化合物的生物利用度、释放时间和作用机理等方面具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
0.10
自引率
0.00%
发文量
17
审稿时长
10 weeks
期刊最新文献
PROBLEMAS DE QUALIDADE DE INSUMOS VEGETAIS NO SETOR MAGISTRAL BRASILEIRO: UMA ANÁLISE DA LITERATURA E DE CERTIFICADOS DE FARMÁCIAS DE MARINGÁ, PARANÁ, BRASIL AVALIAÇÃO FARMACOGNÓSTICA DE PERESKIA ACULEATA MILL. (CACTACEAE) PROPOSTA DE ORIENTAÇÃO FARMACÊUTICA NA ALTA HOSPITALAR A PARTIR DE OVERVIEW E EXPERIÊNCIAS PROFISSIONAIS MORFOANATOMÍA COMPARADA DE DOS ESPECIES DE “JAGUARETÉ KA’A” – BACCHARIS CRISPA SPRENG. Y B. TRIMERA (LESS.) DC. (ASTERACEAE) – UTILIZADAS CON FINES MEDICINALES EN PARAGUAY AUTOMEDICAÇÃO: HÁBITOS DURANTE UM PERÍODO DE PANDEMIA – ESTUDO TRANSVERSAL
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1