Rosemary Wangensteen, Oscar Fernández, Juan Sainz, Andrés Quesada, Félix Vargas, Antonio Osuna
{"title":"Contribution of endothelium-derived relaxing factors to P2Y-purinoceptor-induced vasodilation in the isolated rat kidney","authors":"Rosemary Wangensteen, Oscar Fernández, Juan Sainz, Andrés Quesada, Félix Vargas, Antonio Osuna","doi":"10.1016/S0306-3623(01)00091-X","DOIUrl":null,"url":null,"abstract":"<div><p>We examined the role of endothelium-derived relaxing factors nitric oxide (NO), endothelium-derived hyperpolarising factor (EDHF), and prostaglandins (PGs) to P<sub>2Y1</sub>- and P<sub>2Y2</sub>-purinoceptor-induced vasodilation in isolated rat kidney. To do it, we analysed the renal response to ATP, 2-methylthio ATP, and UTP in rat renal vasculature under normal conditions and after the administration of: <em>N</em><sup>w</sup>-nitro-<span>l</span>-arginine (<span>l</span>-NAME), increased K<sup>+</sup> concentration, indomethacin, and <span>l</span>-NAME and increased K<sup>+</sup> together. Our results indicate that the vasodilator response to P<sub>2Y1</sub>- and P<sub>2Y2</sub>-purinoceptor activation in the isolated perfused kidney of rats is subserved by EDHF and NO.</p></div>","PeriodicalId":12607,"journal":{"name":"General Pharmacology-the Vascular System","volume":"35 3","pages":"Pages 129-133"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0306-3623(01)00091-X","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General Pharmacology-the Vascular System","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S030636230100091X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
We examined the role of endothelium-derived relaxing factors nitric oxide (NO), endothelium-derived hyperpolarising factor (EDHF), and prostaglandins (PGs) to P2Y1- and P2Y2-purinoceptor-induced vasodilation in isolated rat kidney. To do it, we analysed the renal response to ATP, 2-methylthio ATP, and UTP in rat renal vasculature under normal conditions and after the administration of: Nw-nitro-l-arginine (l-NAME), increased K+ concentration, indomethacin, and l-NAME and increased K+ together. Our results indicate that the vasodilator response to P2Y1- and P2Y2-purinoceptor activation in the isolated perfused kidney of rats is subserved by EDHF and NO.
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