Selective Hydrogenation of a,-Unsaturated Aldehydes

IF 9.3 2区 化学 Q1 CHEMISTRY, PHYSICAL Catalysis Reviews-Science and Engineering Pub Date : 1998-02-01 DOI:10.1080/01614949808007106
P. Gallezot, D. Richard
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引用次数: 818

Abstract

Abstract The synthesis of a large number of fine chemicals, particularly in the field of flavor and fragrance chemistry [1,2] and pharmaceuticals [3], involves the selective hydrogenation of unsaturated carbonyl intermediates as a critical step. The hydrogenation of α,β-unsaturated carbonyls into saturated carbonyls is comparatively easy to achieve because thermodynamics favor the hydro-genation of the C═C bonds; therefore, research efforts were more directed at improving the selectivity to unsaturated alcohols. When a substituent is present on the carbon atom of the carbonyl group (i.e. with ketones), there is no chance to hydrogenate selectively the C═O bond, and saturated ketones are obtained with a high yield. This review is thus mostly restricted to the hydrogenation of α, β-unsaturated aldehydes into the corresponding unsaturated alcohols.
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a、-不饱和醛的选择性加氢反应
大量精细化学品的合成,特别是在香精化学[1,2]和药物[3]等领域,都涉及到不饱和羰基中间体的选择性加氢,这是一个关键步骤。α,β-不饱和羰基氢化成饱和羰基相对容易实现,因为热力学有利于C = C键的氢化;因此,研究的重点是提高对不饱和醇的选择性。当羰基的碳原子上存在取代基(即与酮)时,就没有机会选择性地使C = O键氢化,从而获得高收率的饱和酮。因此,本综述主要局限于α, β-不饱和醛加氢成相应的不饱和醇。
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来源期刊
CiteScore
22.30
自引率
2.80%
发文量
29
期刊介绍: Catalysis Reviews is dedicated to fostering interdisciplinary perspectives in catalytic science and engineering, catering to a global audience of industrial and academic researchers. This journal serves as a bridge between the realms of heterogeneous, homogeneous, and bio-catalysis, providing a crucial and critical evaluation of the current state of catalytic science and engineering. Published topics encompass advances in technology and theory, engineering and chemical aspects of catalytic reactions, reactor design, computer models, analytical tools, and statistical evaluations.
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