BIOCHEMICAL IMPROVEMENT INDUCED BY SILYMARIN AND NANO SILYMARIN IN EHRLICH ASCITES CARCINOMA BEARING MICE

Abstract

Silybum marianum (L.) was regarded as one of the wonder plants through the last decades. The main bioactive compound in Silybum marianum is silymarin. Therefore, the present study aimed to evaluate the Silymarin and Nano silymarine activities on mice with induced Ehrlich Ascites Carcinoma (EAC). Sixty Swiss albino female mice (weigh 20–22 g) were randomly divided into equal four groups, 15 rats each. The first one didn't receive any treatment and served as the standard control. Each of the three remaining groups received 2.5 x 10 6 EAC cells intraperitoneally. The second group didn't receive further treatment and served as the EAC control. Silymarine and nano silymarine were administered orally at 100mg/kg b.w dailly for 6 weeks to mice in the third and fourth groups, respectively. Biochemical parameters, including liver and kidney functions as well as lipid profile, were evaluated in all experimental groups. Results revealed that, mice with induced EAC displayed adverse influence on the biochemical parameters. The animals treated with silymarine and nano silymarine extracts exhibited significant improvements in the biochemical parameters following treatment , with a stronger impact in case of nano silymarine.