{"title":"Chemical imaging for Biomedicine","authors":"Lu Wei","doi":"10.1364/OMP.2019.OT3D.3","DOIUrl":null,"url":null,"abstract":"I will present two chemical imaging strategies to address two existing fundamental challenges in optical bio-imaging. First, we devised a Bioorthogonal Chemical Imaging platform suited for probing the dynamics of small bio-molecules. Second, we developed a super-multiplex vibrational imaging method, coupling the narrow Raman linewidth with sensitivity boost from resonance enhancement. It is capable of resolving up to 24 colors simultaneously.","PeriodicalId":8973,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/OMP.2019.OT3D.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract

I will present two chemical imaging strategies to address two existing fundamental challenges in optical bio-imaging. First, we devised a Bioorthogonal Chemical Imaging platform suited for probing the dynamics of small bio-molecules. Second, we developed a super-multiplex vibrational imaging method, coupling the narrow Raman linewidth with sensitivity boost from resonance enhancement. It is capable of resolving up to 24 colors simultaneously.
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生物医学化学成像
我将提出两种化学成像策略来解决光学生物成像中存在的两个基本挑战。首先,我们设计了一个适合探测小生物分子动力学的生物正交化学成像平台。其次,我们开发了一种超多路振动成像方法,将窄拉曼线宽与共振增强带来的灵敏度提升相结合。它能够同时分辨多达24种颜色。
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Niederländische Botschaft / Netherlands Embassy Berlin, DE Timmerhuis Rotterdam, NL Design Museum London, GB Blox Kopenhagen / Copenhagen, DK Casa da Música Porto, PT
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