Bacterial Superantigens as An Agent Provocateur to Initiating Chaos in Immune Response

Abstract

T cell and cytokine-based immune response aids bacterial survival. The current study looked at how healthy people's T cells reacted in vitro to common bacterial sAgs such as SEB and SPE-A. Different Th1 and Th2 cytokines were measured to identify the functional activity of T cells. The findings show that the interaction between PBMC and sAgs has a significant impact on the magnitude of sAg-dependent polyclonal T cell (CD4 + ) elicitation along with cytokine generation in vitro , which is governed by IL-4 and IL-10 releasing cells. Infection-related sAg-activity possibly influences the clinical outcome of the infection, implying that sAg-activated T cells and cytokines play a crucial role in initiating immunity-related diseases.