Extraction and characterization of opuntia stricta cladodes mucilage as pharmaceutical excipient

F. Tamboli, Asavari R. Rasam, S. S. Patil, Vishal T. Khade, Shubham S. Bavkar, Shivtej S. Gaikwad, S. Killedar
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Abstract

This study deals with extraction and characterization of mucilage extracted from cladodes of Cactus () as pharmaceutical excipient. With the use Acetone based extraction method, the yield of mucilage was found to be 1.44%. Characterization of the extracted mucilage was done by various parameters such as micromeritic studies, flow behavior, organoleptic properties, surface tension and viscosity, loss on drying, ash value and swelling index. The result showed that extracted mucilage exhibited good flow properties (Angle of repose 25.30°), the surface tension of 2.85% w/v solutions of mucilage was found to be 70.20 N/m, total ash was 28.33% w/w, loss on drying was 13% and pH was found to be in the range of 7.2-7.4. Extracted mucilage was soluble in warm water and slightly soluble in cold water while insoluble in organic solvents except chloroform. Phytochemical screening and powder characteristics of extracted mucilage powder of cladodes showed that it can be safely used in dosage form without causing any adverse effect.
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药用辅料蓖麻粘液的提取及性质研究
本文研究了仙人掌枝胶液作为药用辅料的提取与表征。采用丙酮基提取法,浆液得率为1.44%。通过显微实验、流动特性、感官特性、表面张力和粘度、干燥损失、灰分值和膨胀指数等参数对提取的黏液进行表征。结果表明,提取的黏液具有良好的流动特性(静息角25.30°),2.85% w/v溶液的黏液表面张力为70.20 N/m,总灰分为28.33% w/w,干燥损失为13%,pH值在7.2 ~ 7.4范围内。提取的粘液可溶于温水,微溶于冷水,不溶于除氯仿以外的有机溶剂。经植物化学筛选和粉末特性分析表明,其可安全作为剂型使用,不会产生任何不良反应。
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