Silylation of thymol extracted from Thymus migricus essential oil, improvement of lipophilicity properties, and investigation of its pharmacological properties

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Main Group Chemistry Pub Date : 2023-02-24 DOI:10.3233/mgc-230005
E. Rezaii, Leila Nazmi Miardan, M. Mahkam, M. Rezaii
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Abstract

Thymus species are well known as medicinal plants because of their biological and pharmacological properties. Thymus migricus Klokov & Desj. -Shos belongs to Lamiaceae. Young branches of this plant produce an essential oil that is abundant in potent and volatile compounds that have a variety of therapeutic uses. In this study, the natural composition of thymol in this plant’s essential oil was first detected with HPLC and Mass, and then the essential oil was extracted. The increase in the lipophilicity of the synthesized silylated derivatives was then examined by HPLC after numerous silylated derivatives of this phenolic compound were synthesized using various silylation reagents. These derivatives were then analyzed by FT-IR and 1HNMR analysis. The antibacterial activity of thymol with its silylated derivatives against gram-negative and gram-positive bacteria was next tested by diffusion method, after which the antioxidant activity of thymol with its silylated derivatives was assessed by two DPPH and FRAP methods.
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麝香精油中百里酚的硅基化、亲脂性的改善及其药理学性质的研究
胸腺属植物因其生物学和药理特性而被公认为药用植物。Thymus migricus Klokov & Desj-Shos属Lamiaceae。这种植物的幼枝产生一种精油,这种精油富含强效和挥发性化合物,具有多种治疗用途。本研究首先采用高效液相色谱法和质谱法检测该植物挥发油中百里酚的天然成分,然后对其进行提取。用不同的硅基化试剂合成了该酚类化合物的大量硅基化衍生物后,用HPLC检测了所合成的硅基化衍生物的亲脂性。然后用FT-IR和1HNMR分析分析这些衍生物。采用扩散法测定百里香酚及其硅基化衍生物对革兰氏阴性菌和革兰氏阳性菌的抑菌活性,采用DPPH法和FRAP法测定百里香酚及其硅基化衍生物的抗氧化活性。
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来源期刊
Main Group Chemistry
Main Group Chemistry 化学-化学综合
CiteScore
2.00
自引率
26.70%
发文量
65
审稿时长
>12 weeks
期刊介绍: Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.
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