Clinical studies of thyrotropin and thyrotropin-releasing-hormone

Michael D. Okerlund, Francis S. Greenspan
{"title":"Clinical studies of thyrotropin and thyrotropin-releasing-hormone","authors":"Michael D. Okerlund,&nbsp;Francis S. Greenspan","doi":"10.1016/S0362-5486(77)80014-9","DOIUrl":null,"url":null,"abstract":"<div><p>Most clinical studies with thyrotropin have utilized bovine TSH since human TSH has not been available, but more general use of the latter may be possible in the near future. The use of BTSH has been limited to stimulation testing of thyroid function, and the compound has shown lesser, but occasional, usefulness in the treatment of metastatic thyroid carcinoma.</p><p>The radioimmunoassay of HTSH has largely replaced the TSH stimulation test in the differential diagnosis of hypothyroidism and has become a valuable tool in the management of thyroid disease. More recently the availability of synthetic TRH has opened a new aspect to the understanding of hypothalamic-pituitary-thyroid interrelationships. The TRH test has also become important in the diagnosis and management of thyroid disease. The role of TRH in the therapy of hypothalamic or thyroid disease is yet to be determined and its usefulness in psychological investigations will no doubt be studied further.</p></div>","PeriodicalId":101017,"journal":{"name":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","volume":"2 1","pages":"Pages 79-94"},"PeriodicalIF":0.0000,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0362-5486(77)80014-9","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0362548677800149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Most clinical studies with thyrotropin have utilized bovine TSH since human TSH has not been available, but more general use of the latter may be possible in the near future. The use of BTSH has been limited to stimulation testing of thyroid function, and the compound has shown lesser, but occasional, usefulness in the treatment of metastatic thyroid carcinoma.

The radioimmunoassay of HTSH has largely replaced the TSH stimulation test in the differential diagnosis of hypothyroidism and has become a valuable tool in the management of thyroid disease. More recently the availability of synthetic TRH has opened a new aspect to the understanding of hypothalamic-pituitary-thyroid interrelationships. The TRH test has also become important in the diagnosis and management of thyroid disease. The role of TRH in the therapy of hypothalamic or thyroid disease is yet to be determined and its usefulness in psychological investigations will no doubt be studied further.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
促甲状腺素及促甲状腺素释放激素的临床研究
大多数促甲状腺激素的临床研究都使用牛促甲状腺激素,因为还没有人促甲状腺激素,但后者在不久的将来可能会得到更广泛的应用。BTSH的使用仅限于甲状腺功能的刺激试验,该化合物在转移性甲状腺癌的治疗中显示出较少但偶尔的有用性。在甲状腺功能减退的鉴别诊断中,放射免疫法已在很大程度上取代了TSH刺激试验,成为治疗甲状腺疾病的一种有价值的工具。最近合成TRH的可用性为理解下丘脑-垂体-甲状腺相互关系开辟了一个新的方面。TRH试验在甲状腺疾病的诊断和治疗中也变得很重要。TRH在治疗下丘脑或甲状腺疾病中的作用尚未确定,其在心理学研究中的有用性无疑将进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Clinical consequences of microsomal enzyme-induction by antiepileptic drugs The teratogenicity of antiepileptic drugs Clinical pharmacokinetics of antiepileptic drugs in children Clinical correlations of adriamycin pharmacology Obesity and thyroid hormone
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1