Severe pneumonia in patients with systemic lupus erythematosus admitted to the intensive care unit.

IF 1.6 3区心理学 Q2 FAMILY STUDIES Journal of Child and Family Studies Pub Date : 2024-02-01 Epub Date: 2022-03-01 DOI:10.1007/s00393-022-01172-x

Bin Zhang, Luzhao Zheng, Yu Huang

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Abstract

Background: The aim of this study was to investigate clinical characters and prognosis of patients with systemic lupus erythematosus (SLE) and severe pneumonia admitted to the intensive care unit (ICU).

Materials and methods: We conducted a retrospective study that reviewed all clinical records of patients with SLE and severe pneumonia admitted to the ICU between 2008 and 2020.

Results: A total of 86 SLE patients with severe pneumonia during their first ICU admission were enrolled in this study. Most patients were female (n = 71, 82.5%), and the median age was 42.3 ± 14.7 years. The most common organisms were gram-positive bacteria (20.9%), followed by gram-negative bacteria (18.6%) and fungi (10.4%). A total of 31 patients died within 30 days of ICU admission, and the 30-day mortality was 36%. In binary logistic regression analysis, Acute Physiologic and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score and mechanical ventilation were dependently associated with 30-day mortality (odds ratio [OR] 2.97, P = 0.016; OR = 4.02, P = 0.023; OR = 1.52, P = 0.036; respectively). Among the other 55 patients, 5 patients died after discharge from the ICU during the long-term follow-up.

Conclusions: Mortality was high in SLE patients with severe pneumonia admitted to the ICU, and most of the patients died within 30 days of ICU admission.

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入住重症监护室的系统性红斑狼疮患者的重症肺炎。

研究背景本研究旨在调查重症监护病房（ICU）收治的系统性红斑狼疮（SLE）合并重症肺炎患者的临床特征和预后：我们进行了一项回顾性研究，回顾了2008年至2020年间重症监护病房收治的所有系统性红斑狼疮合并重症肺炎患者的临床病历：本研究共纳入了 86 名首次入住重症监护病房并患有重症肺炎的系统性红斑狼疮患者。大多数患者为女性（n = 71，82.5%），中位年龄为（42.3 ± 14.7）岁。最常见的病原体是革兰氏阳性菌（20.9%），其次是革兰氏阴性菌（18.6%）和真菌（10.4%）。共有 31 名患者在入住重症监护室 30 天内死亡，30 天死亡率为 36%。在二元逻辑回归分析中，急性生理学和慢性健康评估 II（APACHE II）评分、序贯器官衰竭评估（SOFA）评分和机械通气与 30 天死亡率相关（几率比 [OR] 分别为 2.97，P = 0.016；OR = 4.02，P = 0.023；OR = 1.52，P = 0.036）。在其他55名患者中，有5名患者在出重症监护室后的长期随访中死亡：结论：重症监护病房收治的重症肺炎系统性红斑狼疮患者死亡率很高，而且大多数患者都在入院后30天内死亡。

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来源期刊

Journal of Child and Family Studies Multiple-

CiteScore

3.60

自引率

4.80%

发文量

300

期刊介绍： Journal of Child and Family Studies (JCFS) international, peer-reviewed forum for topical issues pertaining to the behavioral health and well-being of children, adolescents, and their families. Interdisciplinary and ecological in approach, the journal focuses on individual, family, and community contexts that influence child, youth, and family well-being and translates research results into practical applications for providers, program implementers, and policymakers. Original papers address applied and translational research, program evaluation, service delivery, and policy matters that affect child, youth, and family well-being. Topic areas include but are not limited to: enhancing child, youth/young adult, parent, caregiver, and/or family functioning; prevention and intervention related to social, emotional, or behavioral functioning in children, youth, and families; cumulative effects of risk and protective factors on behavioral health, development, and well-being; the effects both of exposure to adverse childhood events and assets/protective factors; child abuse and neglect, housing instability and homelessness, and related ecological factors influencing child and family outcomes.