Aurelie Tran, Elizabeth Windell, Luke Pumiglia, Amanda P Bettencourt, G. Vercruysse
{"title":"How Did This Happen? Xenograft Conversion to Dermal Scaffolding after Scalding Grease Burn","authors":"Aurelie Tran, Elizabeth Windell, Luke Pumiglia, Amanda P Bettencourt, G. Vercruysse","doi":"10.3390/ebj3030035","DOIUrl":null,"url":null,"abstract":"Xenograft and other biologic dressings have been an integral part of burn care for many years. Porcine graft is both inexpensive and, for partial thickness burns, provides the additional benefit of avoiding painful dressing changes when compared with topical agents. In this case, we discuss a patient suffering from deep partial thickness burns for whom xenograft was used for initial wound coverage. This porcine graft became unexpectedly incorporated, and the patient ultimately underwent operative debridement and autologous re-grafting. The case demonstrates a gap in the understanding of wound-healing mechanisms around porcine xenografts and raises the potential for future innovation in expedited wound healing using xenografting.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ebj3030035","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Xenograft and other biologic dressings have been an integral part of burn care for many years. Porcine graft is both inexpensive and, for partial thickness burns, provides the additional benefit of avoiding painful dressing changes when compared with topical agents. In this case, we discuss a patient suffering from deep partial thickness burns for whom xenograft was used for initial wound coverage. This porcine graft became unexpectedly incorporated, and the patient ultimately underwent operative debridement and autologous re-grafting. The case demonstrates a gap in the understanding of wound-healing mechanisms around porcine xenografts and raises the potential for future innovation in expedited wound healing using xenografting.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.