How Did This Happen? Xenograft Conversion to Dermal Scaffolding after Scalding Grease Burn

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-08-05 DOI:10.3390/ebj3030035
Aurelie Tran, Elizabeth Windell, Luke Pumiglia, Amanda P Bettencourt, G. Vercruysse
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Abstract

Xenograft and other biologic dressings have been an integral part of burn care for many years. Porcine graft is both inexpensive and, for partial thickness burns, provides the additional benefit of avoiding painful dressing changes when compared with topical agents. In this case, we discuss a patient suffering from deep partial thickness burns for whom xenograft was used for initial wound coverage. This porcine graft became unexpectedly incorporated, and the patient ultimately underwent operative debridement and autologous re-grafting. The case demonstrates a gap in the understanding of wound-healing mechanisms around porcine xenografts and raises the potential for future innovation in expedited wound healing using xenografting.
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这是怎么发生的?烫伤性油脂烧伤后异种移植物转化为真皮支架
多年来,异种移植物和其他生物敷料一直是烧伤护理的一个组成部分。猪移植物不仅价格低廉,而且对于部分烧伤,与局部用药相比,还提供了避免痛苦的换药的额外好处。在这个案例中,我们讨论了一个患有深度部分厚度烧伤的患者,异种移植物用于初始伤口覆盖。该猪移植物意外合并,患者最终接受手术清创和自体再移植。该病例表明了对猪异种移植伤口愈合机制的理解存在差距,并提出了未来使用异种移植加速伤口愈合的创新潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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